Materials Strategies for Chronically Stable, High-Precision, Multimodal Bioelectronic Interfaces
Bioelectronic medicine offers a transformative approach to disease management by enabling continuous monitoring and precise modulation of physiological activities. Aided by advanced algorithms, implantable and wearable bioelectronic devices are driving a new paradigm of precision health: deeper insight through high-resolution physiological mapping, smarter diagnosis via continuous analytics for early detection, and personalized therapy using closed-loop, targeted modulation. However, integrating these advanced electronics with soft, dynamic biological tissues remains a major challenge, as most existing systems still rely on bulky, rigid components ill-suited for chronic in vivo applications. In this talk, I will discuss our recent efforts to overcome these limitations through rational material design principles that enable long-term functional stability of multimodal bioelectronic devices. I will highlight strategies for decoupling fundamental material trade-offs, enhancing biointerface performance, and achieving high-fidelity signal transduction under physiological conditions. These advances establish a foundation for next-generation bioelectronic platforms with applications in chronic health monitoring, neuromodulation, and biohybrid systems.