The Wittenberg research group uses biosensors, microscopy, microfluidics, and surface patterning techniques to investigate interactions between biomolecules, in particular lipids and proteins. Research topics include the analysis of lipid-protein interactions that govern cell-cell interactions in the nervous system, the implications of lipid oxidation on biomembrane structure and properties, and the development of platforms for the analysis of individual membrane-bound biological particles.
Selected Recent Publications:
A.M. Baxter, N.J. Wittenberg. Excitation of Fluorescent Lipid Probes Accelerates Supported Lipid Bilayer Formation via Photosensitized Lipid Oxidation. Langmuir 2019, 35, 11542 – 11549.
L.R. Jordan, M.E. Blauch, A.M. Baxter, J.L. Cawley, N.J. Wittenberg. Influence of Brain Gangliosides on Formation and Properties of Supported Lipid Bilayers. Colloids & Surfaces B: Biointerfaces 2019, 183, 110442.
Y-S. Ryu, H. Yun, T. Chung, J-H. Suh, S. Kim, K. Lee, N.J. Wittenberg, S-H. Oh, B. Lee, S-D. Lee. Kinetics of Lipid Raft Formation at Lipid Monolayer-Bilayer Junction Probed by Surface Plasmon Resonance. Biosens Bioelectron 2019, 142, 111568.
C. Lin, E.R. Stedronsky, L.R. Jordan, N.J. Wittenberg, S.L. Regen. A Plug and Socket Approach for Tightening Polyelectrolyte Multilayers. Chem Commun 2018, 54, 9769 – 9772.
M. Vala, L.R. Jordan, A.E. Warrington, L.J. Maher III, M. Rodriguez, N.J. Wittenberg, S-H. Oh. Surface Plasmon Resonance Sensing on Naturally Derived Membranes: A Remyelination-Promoting Human Antibody Binds Myelin with Extraordinary Affinity. Anal Chem 2018, 90, 12567 – 12573.
D. Rodrigo, A. Tittl, N. Ait-Bouziad, A. John-Herpin, O. Limaj, C. Kelly, D. Yoo, N.J. Wittenberg, S-H. Oh, H.A. Lashuel, H. Altug. Resolving Molecule-Specific Information in Dynamic Lipid Membrane Processes with Multi-Resonant Infrared Metasurfaces. Nature Communications 2018, 9, 2160.
Y-S. Ryu, L.R. Jordan, N.J. Wittenberg, S.M. Kim, D. Yoo, C. Jeong, A.E. Warrington, M. Rodriguez, S-H. Oh, S-D. Lee. Curvature Elasticity‐Driven Leaflet Asymmetry and Interleaflet Raft Coupling in Supported Membranes. Advanced Materials Interfaces 2018, 5, 1801290.
C.T. Ertsgaard, N.J. Wittenberg, D.J. Klemme, A. Barik, W-C. Shih, S-H. Oh. Integrated Nanogap Platform for Sub-Volt Dielectrophoretic Trapping and Real-Time Raman Imaging of Biological Nanoparticles. Nano Letters 2018, 18, 5946 – 5953.