Dmitri Vezenov

Associate Professor
(610) 758-3642
Seeley G. Mudd, Room 512
Research Interests: 
Physical and Surface Chemistry
Chemical Force Microscopy
Analytical Microdevices
Teaching Interests: 
Physical chemistry
Thermodynamics and Kinetics
Statistical Mechanics
Scanning Probe Microscopy

In our research, we set the goal of understanding and controlling interactions in chemical systems at small scale (microns to nanometers to single molecules). The research is interdisciplinary, where approaches of chemistry, physics, and engineering converge. In particular, force spectroscopy can manipulate single molecules and perform mechanical experiments at nanoscale; thus, one can move beyond ensemble averages to resolve and analyze transient subpopulations, study details of energy landscapes, and observe mechanics of molecular machinery of cells. We are developing new, simple approaches to the analytical force spectroscopy platform for massively-parallel low cost binding assays.

Selected Recent Publications:

Iliafar, S.; Mittal, J.; Vezenov, D.; Jagota, A. “Interaction of single-stranded dna with curved carbon nanotube is much stronger than with flat graphite” J. Am. Chem. Soc., 2014, 136, 12947-12957.

Wang, T.; Vezenov, D.; Simboli, B. “Use of a wiki-based software to manage research group activities”. Issues in Science and Technology Librarianship, 2014, 77, DOI:10.5062/F4KS6PJ1. 

Yin, P.; Bayaguud, A.; Cheng, P.; Haso, F.; Hu, L.; Wang, J.; Vezenov, D.; WinansR. E.; Hao, J.; Li,T.; Wei, Y.; Liu, T. “Spontaneous stepwise self-assembly of a polyoxometalate–organic hybrid into catalytically active one-dimensional anisotropic structures” Chem. Eur. J., 2014, 20, 9589-9595. 

Iliafar, S.; Vezenov, D.; Jagota, A. “In-plane force–extension response of a polymer confined to a surface” Eur. Polymer Journal, 2014, 51, 151-158. 

Wagner, K.; Wang, Y.; Regen, S.; Vezenov, D. "Yield strength of glued langmuir-blodgett films determined by friction force microscopy” Phys. Chem. Chem. Phys., 2013, 15, 14037-14046. 

Iliafar, S.; Vezenov, D.; Jagota, A. "Brownian dynamics simulation of peeling a stronglyadsorbed polymer molecule from a frictionless substrate" Langmuir, 2013, 29, 1435- 1445. 

Cheng, P.; Oliver, P.M.; Barrett, M.J.; Vezenov, D. “Progress toward the application of molecular force spectroscopy to DNA sequencing.” Electrophoresis, 2012, 33, 3497- 3505. 

Yin, P.; Jin,L.; Li, D.; Cheng, P.; Vezenov, D.; Bitterlich, E.; Zhang, J.; Wu, X.; Peng, Z.; Liu,T.”Supramolecular aggregation of conjugated polymers containing POM-terminal side chains in polar and nonpolar solvents” Chem. Eur. J., 2012, 18, 6754-6758. 

Barrett, M.J.; Oliver, P.M.; Cheng, P.; Cetin, D.; Vezenov, D. “High density singlemolecule-bead arrays for parallel single molecule force spectroscopy” Analyt. Chem., 2012, 84, 4907-4914. 

Iliafar, S.; Wagner, K.; Manohar, S.; Jagota, A.; Vezenov, D. “Quantifying interactions between DNA oligomers and graphite surface using single molecule force spectroscopy”, J. Phys. Chem. C, 2012, 116, 13896-13903. 

Cheng, P.; Barrett, M.J.; Oliver, P.M.; Cetin, D.; Vezenov, D. “Dielectrophoretic Tweezers as a Platform for Molecular Force Spectroscopy in a Highly Parallel Format” Lab Chip201111, 4248 - 4259.

Wagner, K.; P. Cheng; Vezenov, D.V. “Non-contact Method for Calibration of Lateral Forces in Scanning Force Microscopy” Langmuir2011, 4635-4644.

Gan, Q.; Gao, Y.; Wagner, K.; Vezenov, D.V.; Ding, Y.; Bartoli, F. "Experimental verification of the "rainbow" trapping effect in adiabatic plasmonic gratings" Proc. Natl. Acad. Sci.2011, 5169-5173.

Yin, P.; Wu,P.; Xiao,Z.; Li, D.; Bitterlich, E.; Zhang, J.; Cheng, P.; Vezenov, D.V.; Liu,T.; Wei, Y. “A double-tailed, fluorescently active surfactant with hexavanadate as giant polar head group”, Angewandte Chemie2011, 2521-2525.

Oliver, P.M.; Park, J.S.; Vezenov, D.V. “Single Molecule Force Spectroscopy using Magnetic Tweezers with Evanescent Illumination: Quantitative High-Resolution Sensing of DNA Hybridization”, Nanoscale2011, 3, 581–591.

Bijamov, A.; Shubitidze, F.; Oliver, P.M.; Vezenov, D.V. “Quantitative Modeling of Forces in Electromagnetic Tweezers”, J. Appl. Phys.2010108, 104701-1--104701-9.

Lim, H.; Marzillier, J.; Vezenov, D.V. “Heterobifunctional Modification of DNA for Conjugation to Solid Surfaces”, Anal. Bioanal. Chem., 2010, 397, 1861–1872.

Bijamov, A.; Shubitidze, F.; Oliver, P.M.; Vezenov, D.V. “Optical Response of Magnetic Fluorescent Microspheres Used for Force Spectroscopy in the Evanescent Field”, Langmuir201026, 12003–12011.

Fuller, C. W.; Middendorf, L.R.; Benner, S.A.; Church, G.M.; Harris, T.; Huang, X.; Jovanovich, S.B.; Nelson, J.R.; Schloss, J.A.; Schwartz, D.C.; Vezenov, D.V. “Challenges of Sequencing by Synthesis”, Nature Biotech.200927, 1013-1023. Perspective article.

Manohar, S.;  Mantz, A.; Bancroft, K.; Hui, C.-Y.; Jagota, A.; Vezenov, D.V. “Peeling Single Stranded DNA from Graphite Surface to Determine Oligonucleotide Binding Energy by Force Spectroscopy” Nano Lett.20088, 4365-4372.

Vezenov, D.V.; Noy, A.; Lieber, C.M “Chemical Force Microscopy: Force Spectroscopy and Imaging of Complex Interactions in Molecular Assemblies.” in Handbook of Molecular Force Spectroscopy, A. Noy (Ed.), Springer, 2008, pp. 123-143.

Noy, A.; Vezenov, D.V.; Lieber, C.M “Chemical Force Microscopy: Nanoscale Probing of Fundamental Chemical Interactions.” in Handbook of Molecular Force Spectroscopy, A. Noy (Ed.), Springer, 2008, pp. 97-122.